In 2014, we were approached by a leading biotech company looking to generate and analyse sequence data for two biosynthetic clusters that were of interest to their discovery efforts.
Within 6 weeks of the strain arriving at our labs in Cambridge, the team at Isomerase was able to generate high quality genomic DNA, send this for next-gen sequencing, analyse and compile the sequence data and prepare a detailed report for the client outlining the following:
- Key information on the biosynthetic gene clusters coding for the products of interest and related compounds.
- Identification of unknown clusters coding for additional and hitherto unexploited natural products within the strain.
- Outline the potential bioengineering modifications that could be used to deliver the key products
If you would like to learn more about our capabilities to interrogate the biosynthetic capabilities of microbial strains please get in contact with us here